- As a first synthetic antineoplastic anthracenedione
agent, Novantrone inhibits both RNA and DNA synthesis of cancer cell to
be associated with the inhibition of nucleic acid synthesis, resulting in
cell death.
- Novantrone, a consistent finding in clinical studies in various neoplasms
has been a lower frequency and usually lesser intensity of acute side effects
coming out from traditional anthracyclines such as cardiotoxicity and nausea,
vomiting, alopecia, and stomatitis
Acute Myeloblastic Leukemia(AML) & Acute Lymphoblastic
Leukemia(ALL), Advanced Breast Cancer(ABC), Non-Hodgkin's Lymphoma(NHL),
Prostate Cancer